Three dogs and 17 week-old Springer Spaniel puppies have been stolen from a breeding pen in Selston.
Police say the theft happened overnight between Saturday and Sunday (November 11 and 12) in Station Road, Selston.
Police say the thieves got in through the garden of the property before breaking into the pen.
Officers released pictures of the dogs and appealed for anyone who is offered them for sale or has any information to contact them.
One of the older dogs stolen is white all over with liver-coloured ears and another has three large liver-coloured spots down her back with a shaved back leg, which was stitched two weeks ago.
Anyone with information is asked to contact police on 101, quoting incident number 196 of November 12.