The A60 Mansfield Road north of Nottingham is open again after a serious collision between the Ravenshead and the Seven Mile Inn turn-offs.
Six people were taken to hospital following the collision, including a 22-year old woman who remains in a critical condition.
Notts Police say a 23-year old man has been arrested following the crash.
Police crash investigators are keen to speak to anyone who may have seen a dark-coloured people carrier or dark-coloured car with distinctive chequered roof as they travelled along the A60 between Nottingham and Mansfield in the time leading up to the crash.
It happened just before 11pm on Saturday night and led to the closure of the road until late on Sunday morning.